stability of pantoprazole

Discovery and development of proton pump inhibitors

Pantoprazole obtained high selection criteria in its development process — especially concerning the favorable low potential for interaction with other drugs Good solubility of pantoprazole and a very high solution stability allowed it to become the first marketed PPI for intravenous use in

Extended Stability of Pantoprazole for Injection in 0 9%

Pantoprazole Stability in PVC Minibags The initial concentration and the observed percentage remaining on each study day for each pantoprazole solution are listed in Table 1 The observed initial concentrations were about 0 15 mg/mL and 0 88 mg/mL This indicates that the overfill in the PVC minibags was closer to 3 mL rather than the assumed

DailyMed

Dec 30 2013Pantoprazole has weakly basic and acidic properties Pantoprazole sodium sesquihydrate is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent The rate of degradation increases with decreasing pH

Stability of Pantoprazole Sodium in Glass Vials Polyvinyl

The study also examined the stability of EDTA-free pantoprazole sodium diluted to 0 4 or 0 8 mg/mL in either 5% dextrose in water (D5W) or 0 9% sodium chloride (normal saline [NS]) and packaged in polyvinylchloride (PVC) bags with storage for 3 days at room temperature with exposure to light or for 28 days under refrigeration with protection

Stability of Pantoprazole in Parenteral Nutrition Units

Jan 01 2008Introduction Pantoprazole is a weak base (pka ∼ 4) with its stability in aqueous solution dependent on pH Keeping in mind that the pH of the parenteral nutrition units (PNU) can range between 6 0 and 6 5 and since pantoprazole seems to be the most stable proton pump inhibitor (PPI) for pH acid we want to assess the possibility of adding it to PNU with the aim of simplifying its

PROTONIX I V (pantoprazole sodium) for Injection

Pantoprazole sodium is a white to off-white crystalline powder and is racemic Pantoprazole has weakly basic and acidic properties Pantoprazole sodium is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent

PROTONIX(pantoprazole sodium)Delayed

The stability of the compound in aqueous solution is pH-dependent The rate of degradation increases with decreasing pH At ambient temperature the degradation half-life is approximately 2 8 hours at pH5 0 and approximately 220 hours at pH7 8 PROTONIX (pantoprazole sodium) is supplied as a delayed-release tablet for oral

DailyMed

Aug 06 2020Pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of approximately 36 mcg/L and 24 mcg/L respectively A milk-to-plasma ratio of 0 022 was observed at 2 hours after drug administration Pantoprazole was not detectable (10 mcg/L) in milk at 6 8 and 24 hours after the dose

Stability of Pantoprazole Sodium in Glass Vials Polyvinyl

Objective: To determine the physical compatibility and chemical stability of ethylenediaminetetra-acetic acid (EDTA)-free pantoprazole in glass vials polypropylene syringes and polyvinylchloride (PVC) minibags after storage at 2C to 8C with protection from light or at 20C to 25C with exposure to light

Pantoprazole 40 mg gastro

Pantoprazole is rapidly absorbed and the maximal plasma concentration is achieved even after one single 40 mg oral dose On average at about 2 5 h p a the maximum serum concentrations of about 2 - 3 g/ml are achieved and these values remain constant after multiple administration

Stability of Pantoprazole Sodium in Glass Vials Polyvinyl

Stability of Pantoprazole Sodium 4 mg/mL in 0 9% Sodium Chloride after Storage in Glass Vials at Room Temperature (20C to 25C) with Exposure to Light Table 2 Stability of Pantoprazole Sodium 4 mg/mL in 0 9% Sodium Chloride after Storage in Polypropylene Syringes under Refrigeration (2C to 8C) with Protection from Light

Stability of Pantoprazole Sodium in Glass Vials Polyvinyl

The study also examined the stability of EDTA-free pantoprazole sodium diluted to 0 4 or 0 8 mg/mL in either 5% dextrose in water (D5W) or 0 9% sodium chloride (normal saline [NS]) and packaged in polyvinylchloride (PVC) bags with storage for 3 days at room temperature with exposure to light or for 28 days under refrigeration with protection

Pantoprazole

Pantoprazole is a substituted benzimidazole and proton pump inhibitor with antacid activity Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated producing the active metabolite sulphenamide which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the

Pantoprazole Sodium Information Side Effects Warnings

Pantoprazole has weakly basic and acidic properties Pantoprazole sodium (sesquihydrate) USP is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent The rate of degradation increases with decreasing pH

Stability

Pantoprazole Degradation products Introduction Instability of pharmaceuticals affects both the safety and efficacy of drug therapy Therefore appropriate analytical stability-indicating methods which allow accurate and precise drug quantitation in the presence of its degradation products are needed in order to assess the stability of

US7550153B2

US7550153B2 US11/731 474 US73147407A US7550153B2 US 7550153 B2 US7550153 B2 US 7550153B2 US 73147407 A US73147407 A US 73147407A US 7550153 B2 US7550153 B2 US 7550153B2 Authority US United States Prior art keywords multiparticulates method according pantoprazole mg coat Prior art date 2003-10-01 Legal status (The legal status is an assumption and

Pantoprazole Sodium Delayed Release Tablet and Oral Suspension

Pantoprazole has weakly basic and acidic properties Pantoprazole sodium sesquihydrate is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent The rate of degradation increases with decreasing pH

PROTONIX I V (pantoprazole sodium) for Injection

Pantoprazole sodium is a white to off-white crystalline powder and is racemic Pantoprazole has weakly basic and acidic properties Pantoprazole sodium is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent

Pantoprazole

Stability of pantoprazole in an extemporaneously compounded oral liquid Am J Health-Syst Pharm 2002 59:953-956 • Jew RK et al Extemporaneous Formulations for Pediatric Geriatric and Special Needs Patients 2nd Ed American Society of Health-System Pharmacists Bethesda MD 2010

PROTONIX

Pantoprazole has weakly basic and acidic properties Pantoprazole sodium sesquihydrate is freely soluble in water very slightly soluble in phosphate buffer at pH 7 4 and practically insoluble in n-hexane The stability of the compound in aqueous solution is pH-dependent The rate of degradation increases with decreasing pH

Pantoprazole Sodium Delayed

Revision Bulletin Official December 1 2009 Pantoprazole1 Add the following: sponses for the major peaks Calculate the amount of pantoprazole released in the Acid stage by the formula: •Pantoprazole Sodium Delayed-Release Tablets in which r U and r S are the peak responses of pantoprazole obtained from the solution under test and the Working standard solution re-

Formulation and stability evaluation of enteric

Formulation and stability evaluation of enteric -coated omeprazole formulations S Bozda S al and M umnu S T P PHARMA SCIENCES 9 (4) 321-327 1999 samples were removed from the release medium and assayed by means of UV spectrophotometry at 303 nm The same procedure was used in the stability studies for the evaluation of

Formulation Development and Evaluation of Pantoprazole

Key-words: Pantoprazole Enteric Coated Development and Evaluation 1 Introduction: The tablet coating is perhaps one of the oldest pharmaceutical processes still in existence1 It offers many benefits namely – improving the aesthetic quality of the dosage form masking unpleasant order or test easing ingestion improving product stability and

Stability of Lansoprazole in Extemporaneously Compounded

Stability of Lansoprazole in Extemporaneously Compounded Suspensions for Nasogastric or Oral Administration Mary H H Ensom Diane Decarie and Ian Sheppard ABSTRACT Objective: To evaluate the stability of extemporaneously com-pounded lansoprazole suspensions for nasogastric or oral administration after storage at 4C and 25C for up to 91 days

Stability of Lansoprazole in Extemporaneously Compounded

Stability of Lansoprazole in Extemporaneously Compounded Suspensions for Nasogastric or Oral Administration Mary H H Ensom Diane Decarie and Ian Sheppard ABSTRACT Objective: To evaluate the stability of extemporaneously com-pounded lansoprazole suspensions for nasogastric or oral administration after storage at 4C and 25C for up to 91 days

Compatibility of proton pump inhibitors in a preservative

Nov 25 2016Also for the first time microbiological stability was determined for these suspensions and antimicrobial effectiveness testing was performed for the vehicle Beyond-use dates of 60 days for omeprazole (5 mg/mL) pantoprazole (3 mg/mL) and esomeprazole (3 mg/mL) were established

Stability of Omeprazole Solutions at Various ph Values as

Oct 20 2008The developed method was used to study the effect of pH on the stability of omeprazole and to quantify the drug in capsules The excipients present in the capsules did not interfere with the assay procedure The pH-rate profile curve indicated that the maximum stability was at pH 11 Below pH 7 8 the decomposition was very fast

Nefopam hydrochloride compatibility and stability with

Background: The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability Objective: To assess the physical compatibility and the chemical stability of nefopam hydrochloride a centrally acting non‐opioid analgesic when admixed with selected proton pump inhibitors (omeprazole esomeprazole or pantoprazole) in bionolyte G5